CBD Safe for Patients with Bleeding Complications? As cannabis becoming socially and worldwide acceptable, many cannabinoids draw attention to the health benefits they’re providing. The The short answer is – no, in most cases cannabis and specific cannabinoids do not seem to act as strong blood thinners. Does CBD Thin Your Blood? A question that has been messaged to me multiple times over the past month, I wanted to cover off whether CBD thins your blood, how different products might affect this
CBD Safe for Patients with Bleeding Complications?
As cannabis becoming socially and worldwide acceptable, many cannabinoids draw attention to the health benefits they’re providing. The production of industrial hemp is increasing from year to year. This plant of the future, thanks to its wide range of activities bring positive interest around the world.
Previous research shows that CBD oil can be successfully used in the treatment of many diseases. Thanks to the beneficial effect of CBD oil, it is possible to reduce pain, inflammation, as well as other symptoms of various diseases.
Cannabidiol (CBD) is the most important phytocannabinoid or the second most common cannabinoid in various plant-derived drugs. Recently, the interest in the therapeutic potential of CBD is rapidly growing, as it does not cause psychotropic effects or other side effects. It is well-tolerated, even in high doses.
Nonetheless, there are some doubts about CBD treatment for bleeding disorders. You should be aware of the risks and the benefits of using CBD if you have a bleeding complication. This article explains the possible effect and safety of using CBD for this condition.
What Is a Bleeding Complication?
When you get cut, you start to bleed because you got injured. Your body contains blood clotting factors that will stop your bleeding. If the blood does not clot normally, you may have problems with uncontrolled bleeding. In this situation, you are missing a factor of coagulation. This is very important, especially after a surgery or injury. You can inherit it, or develop it during your life. Signs may include:
- Easy bruising;
- Heavy menstrual periods;
- Unusual bleeding.
Bleeding disorders include haemophilia, von Willebrand diseases, coagulation diseases, clotting factor deficiencies, and many others.
CBD for Bleeding Disorders
CBD can not cure bleeding disorders. It may help to alleviate the common symptoms such as pain, inflammation, vomiting, and nausea. In one study , in 2011, CBD helps in treating both nausea and vomiting caused by treatments. Also, the treatment medication can lead to addiction, which is why CBD is a better option. It is not addictive, because it doesn’t contain the psychoactive compound (THC).
However, in regular treatment, you should be aware of the possible risk and side effects. In clinical practice , given current doses of medication may increase the risk of a bleeding complication.
CBD can help in treating the signs and symptoms of these conditions. Various benefits include:
- A pain reliever;
- Relieve the symptoms of internal bleeding;
- Prevent having nausea and vomiting;
- Relieve headaches, etc.
CBD Acts as Blood Thinner
CBD may act as a blood thinner (anticoagulant), which means can help to reduce the formation of blood clots. When you take it together with other anticoagulants such as Coumadin (Warfarin), it may contribute to additional blood thinning. Like all medicines, warfarin has many common serious adverse effects , such as significant bleeding. In this case, CBD is a better alternative, because it has minimal to no side effects.
CBD affects platelets (important for blood coagulation) by suppressing their production. Thus, it can potentially increase the bleeding. So, it appears that CBD may thin the blood and you should use it with caution. Especially, if you are struggling with a bleeding disorder like haemophilia and other coagulation conditions.
Is CBD Safe for People with Bleeding Disorders?
In general, CBD in clinical trials showed significant results for many conditions and proved to be safe. The dosage and route of administration depend on the severity of your current condition. For treating some diseases, using only a single dosage of CBD showed a positive effect.
If you suffer from a bleeding disorder, you should be very careful when taking CBD. CBD may additionally thin your blood, which can lead to serious bleeding and problems. Excessive bleeding can be life-threatening. Because CBD does not have strong anticoagulants effects, it cannot replace the traditional treatments for bleeding disorders. Bellow is a great example to explain more about CBD safety for these disorders.
Treating Hemophilia A with CBD
Hemophilia A is a genetic bleeding disorder where your blood doesn’t clot normally without medication. If you have haemophilia A, you may experience spontaneous bleeding, both external and internal. Because CBD is not an option when talking about curing, you should use it for your signs and symptoms. It is a possible and the best solution because it can alleviate the symptoms. Other painkillers may be dangerous, and that’s why there is a limitation with the treatment for this disorder.
The common side effects from the treatment are pain, nausea, vomiting, headache and fever. CBD may efficiently fill the gap in symptoms management. To relieve the pain, it binds to the pain receptors in the nervous system in the brain.
Possible Side Effects of CBD in Bleeding Conditions
Because traditional medications may cause severe side effects, may also impact the effects. Once you stopped taking them, there is a possibility to start bleeding again.
Like many medicines, CBD may have some possible side effects. Even though they are mild and rare, we should mention they may occur in some people. The most common is excessive bleeding due to the ability to encourage blood flow. Other side effects may include:
- Increased appetite;
- Dry mouth;
- Insomnia, etc.
However, to avoid these symptoms you should consult with your doctor about the right dosage and combination of medications. You should always start with a smaller dosage of CBD and increased it over time if needed.
CBD is a potential solution for managing symptoms of bleeding disorders. Keep in mind that you should use CBD in the right way, dosage and find a good CBD seller for the best quality product. For that purpose, you should consult your doctor, especially if you are suffering from one of the ailments mentioned above. If you live in California, you can contact dispensaries that provide weed delivery in San Francisco to quickly enjoy the warm fragrances of canna tea.
CBD shows very promising results in easing the symptoms due to its anti-inflammatory properties. If you have bleeding disorders or history in your family, see a professional before starting with it. Apart from the usual treatments, using CBD as a natural supplement will have many benefits to your health in general.
Is cannabis a blood thinner?
Ever wondered how cannabinoids like THC or CBD affect your blood? It may seem like a weird question, but it is a vitally important one for anyone taking anticoagulant medications and considering using cannabis. It turns out that this issue has been under-researched and could have significant impacts on patients who may be at greater risk of heart attacks and strokes.
What is a blood thinner?
It is not uncommon for patients at a high risk of blood clots and strokes to receive medications called “anticoagulants” or “antiplatelet drugs”, often generically referred to as “blood thinners.” These drugs do exactly what you might expect – prevent blood from forming a clot. It is important to note that while clotting is good and necessary when you have a cut or injury, forming a clot inappropriately can be highly dangerous. Blood clots can greatly interrupt blood flow to the surrounding tissue, causing serious damage to important organs, and sometimes death. Some common examples of anticoagulant blood thinning medications on the market include warfarin (Coumadin), heparin, apixaban (Eliquis), and enoxaparin (Lovenox). One of the most common examples of an antiplatelet drug is aspirin.
How do blood thinners work?
Blood thinners typically act in one of two ways – as anticoagulants or antiplatelets. But before we explain how these drugs work, it is important to understand a couple of things about blood clotting in the human body.
Blood consists of several primary constituents including plasma, red blood cells, white blood cells, and platelets. Whenever we injure ourselves and break a blood vessel, causing bleeding, platelets start to attach to the damaged tissue and act as a kind of cork that plugs the hole in the blood vessel. 1
Blood thinners disrupt the blood clotting process in one of two ways. Anticoagulants typically slow down the process of blood clotting by interrupting clotting factors, whereas antiplatelet drugs prevent platelets from coming together to form blood clots in the first place.
Typically, “blood thinners” refer to anticoagulants, though you may find the term “blood thinner” applied to either anticoagulants or antiplatelet drugs.
Does weed thin your blood?
The short answer is – no, in most cases cannabinoids do not seem to act as strong blood thinners. There are very few case studies that report anticoagulant effects in cannabis patients, and the ones that do exist involve using cannabis with traditional anticoagulant medications. 2
While the general concensus is that phytocannabinoids (derived from the cannabis plant) do not cause anticoagulations, there has been only one study that found that THC, CBD and CBN could thin the blood of obese rodents. Preclinical rodent studies are challenging to interpret, however, as the results very often don’t directly scale to the human biological system. In this study the authors speculated that cannabinoids may be inhibiting an enzyme in blood plasma called thrombin, which promotes blood clotting. Additionally, the authors noted that THC (and CBD for that matter) are known to interact with receptors known as PPARy 3 , which are highly present in blood vessels. Lastly the authors note that certain endocannabinoids like anandamide may promote clotting, but these tests were in vitro (aka in a laboratory test-tube), not in a living animal. 4
There have also been reports that synthetic cannabinoids, aka spice or K2, may cause blood thinning due to contaminants found mixed with the cannabinoids. Basically, rat poison designed to work by making rodents bleed to death is occasionally mixed with synthetic cannabinoids, either accidentally or as a cutting agent, which can cause coagulopathy (aka inappropriate clotting). In this case, hundreds of patients were seen in emergency departments in 2018 with signs of bleeding with no known cause. It was later found that many of these patients had been consuming synthetic cannabinoid products, and these products were contaminated with rat poison. This is yet another cautionary tale regarding synthetic cannabinoids and another reason why cannabis regulations allowing for safe access to cannabis are so important. 5 6
Is it safe to use THC with blood thinners?
This is a tricky one given the lack of research. In general patients taking anticoagulants often have cardiovascular issues, which can be problematic with cannabis use as THC is known to cause changes in heart rate and blood pressure. This effect is particularly strong with smoking or vaping THC products, but can also happen with edibles. So it follows that THC should likely be avoided if a patient is taking blood thinners.
If a patient is taking anticoagulants, that could indicate that their cardiovascular system may not be in the best of health to begin with. This can be problematic with cannabis use, in particular THC which is known to cause changes in heart rate and blood pressure. Generally, patients with high risks of strokes, heart attacks and other cardiovascular dysfunction are those most commonly prescribed blood thinners. Since THC carries its own risk of exacerbating cardiovascular issues in susceptible users and should likely be avoided if a patient is taking blood thinners. 7
As far as THC’s anticoagulant effects are concerned, there is very limited evidence that THC may act as an anticoagulant by inhibiting thrombin, but that evidence is in rodents and stems from only one study mentioned previously. The real concern about THC in this population is actually related to blood pressure, heart rate and heart rhythm; an older heart may be even more susceptible to these changes. 8 9
CBD and Blood Thinners
As mentioned previously, CBD is a known PPARy receptor agonist, causing vasorelaxation and lowering blood pressure. CBD is also known to interfere with the normal function of certain enzymes already inside of us, known as cytochrome P450 enzymes. These CYP450 enzymes are all over our bodies and play important roles in metabolizing food and drugs. Cannabidiol is a known inhibitor of some CYP enzymes, leading to an increased risk of pharmaceutical drug interactions. And CBD is not alone in this effect. Many other phytocannabinoids do carry this potential to interfere with liver enzymes – though all of them do so with lesser potency than CBD. In simple terms, CBD can slow the body’s ability to break down common medications – including blood thinners.
There are multiple case reports available which detail situations in which patients have experienced herb-drug or drug-drug interactions between CBD and a common anticoagulant, warfarin (Coumadin). In one instance, a 46-year-old male patient required a nearly 20% reduction in their warfarin dose after beginning Epidiolex, a pharmaceutical containing CBD isolate in a liquid solution. In another instance, a 44 year-old male patient required a 30% dose reduction in warfarin after starting to use CBD oil. There was, however, one case report where this drug interaction did not occur. 10 11 12 13 14
These drug interactions highlight some important lessons. First, it is important to recognize that pharmaceutical interactions with cannabis are very real and can be dangerous if not monitored properly – especially in the context of drugs like blood thinners. However, there is a flip side to this drug interaction issue. Oftentimes, if a patient and their physician are aware of these potential interactions, it’s possible a patient could choose to continue using anticoagulants and cannabis together. This combination would likely warrant close monitoring of the anticoagulant effects, and would certainly require increased communication between the patient and the medical provider. But if monitored properly, it’s possible that the dose of patient’s anticoagulants could be reduced, possibly reducing the risk of serious negative side effects from those medications while still deriving benefit from the cannabinoids.
Bottom line: Talk to your healthcare provider
So what does all of this mean? Is marijuana a blood thinner?
According to the miniscule amount of research that has been performed so far on this topic, it is possible that cannabinoids like THC or CBD could act as anticoagulants, and the endocannabinoid system is involved in platelet aggregation. However, it appears this effect may only be in certain contexts, for instance, in the rodent study that identified anticoagulant effects of THC, CBD and CBN, the rodents were obese rodents in a simulated Type-2 diabetes model. In that scenario, cannabinoids exhibited anticoagulant effects by inhibiting the blood clotting signaling compound thrombin. However, we do not know how that would scale up to humans with Type 2 diabetes or other conditions. 15
We do know that cannabinoids can interact negatively with blood thinning medications, either by inhibiting their breakdown and elevating their concentrations in the body or by preventing their activation. In both cases, this can be extremely dangerous for patients, as coagulation of blood is a fine balance of clotting and bleeding, and the result of managing these medications poorly can be as serious as death. This is why it is so important to talk to a healthcare professional if you plan to try using cannabis in combination with anticoagulant and antiplatelet medications. Your physician can arrange regular blood tests to monitor for interactions with other medications and take appropriate steps as needed to keep you safe.
So for now, the jury is still out. There is a tiny bit of preclinical evidence that cannabinoids may affect blood’s ability to clot, but a lot more research is still needed. However if you combine cannabis products, especially CBD, with your anticoagulant or antiplatelet medication, be sure to take extra caution to monitor the effects with your doctor.
Does CBD Thin Your Blood?
A question that has been messaged to me multiple times over the past month, I wanted to cover off whether CBD thins your blood, how different products might affect this and why this is important for you.
As you take CBD oil, one of the side effects is it can increase the quantity of coumadin, which is known to thin your blood. Coumadin, also known as Warfarin Sodium, is an anticoagulant, which means it thins the blood and extends the time it takes to clot the blood. As you can imagine, there are many medical reasons why this might be wanted.
CBD has been shown in multiple studies to dilate blood vessels, which in turn helps the circulatory system, such as this test which showed a small quantity had a significant impact on the test subjects blood pressure in stress situations.
Another test, performed on an obese rat (again, another reason why we need more human testing as most of the tests are based on rats currently) showed that the cannabis extract had the anticoagulant effect they were aiming for.
For anyone who hasn’t heard of the grapefruit effect, it is that taking a grapefruit when having a blood thinner medication can have an effect on the medicine working. The main medicines that are affected by eating grapefruits include statins, calcium channel blockers, entocort, cyclosporin and cytotoxic medicines. It should be stated that this isn’t a definitive list, there are many more, which is why you must speak to your doctor.
It affects the medicine by increasing the amount in your blood, which can obviously have side effects or change the way it is meant to work.
The same effects have been seen when taking CBD oil, therefore if you are taking any of these medications then it might not be recommendable to have CBD oil.
Considering all of these factors, this is why it is even more important that the brands are held to account and deliver the quantities they state on the pack. As it stands, they are registered as food supplements rather than medicine, meaning the regulations are more relaxed, so you should read up on the third party lab test results and only opt for reputable brands. Ignore anything which is being produced in China, I promise you that!
Is There A Difference Between Topical & Oral?
Absolutely, in most tests, when taken topically (on the skin, such as a cream), it didn’t thin your blood, meaning you could gain all the benefits associated with a CBD cream without the worry of what it might do if on medication. Having said that, people who are taking CBD oil sublingually are normally after a very different treatment than if they are using a cream.
None Before Tattoo’s
Just the same as being told you can’t take painkillers or drink alcohol before getting a tattoo, as the blood becomes very thin, pours out and makes it much harder for the artist, the exact same has been witnessed with CBD oil. Obviously, this is a frustration for people who were hoping to take it to calm their nerves before getting this procedure done.
Just the same, you might want to consider this if you are having any work done or an operation. It might help to calm your nerves, but the doctor will have to know about this and will most likely to tell you not to take any in the days leading up to this, but once again, you should speak to a medical professional beforehand.
Does That Mean It Is A Bad Thing?
No, absolutely not, this could be opening up huge new opportunities to tackle some of our biggest health issues, such as strokes and heart disease. Having said that, we need a huge amount more test studies to be taken before anyone can state one way or the other.